Active substance Sofosbuvir + Ledipasvir
US Brand Generic Harvoni
IN Brand Ledifos | Hepcinat LP | MYHEP | LEDIHEP
Manufacturing by Hetero | Natco | Mylan | Zydus
Strength 400mg + 90mg
Form release Bottle 28 tablets
Estimated shipping time 7 – 18 days (Depending from the Country)
Availability, Prices & Order through request form

DescriptionDosageSide EffectsPhotos

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

The fixed dose combination of ledipasvir-sofosbuvir provides a very attractive and effective one pill once a day option for treatment of genotypes 1, 4, 5, and 6 chronic hepatitis C infection. This regimen is the first FDA-approved interferon- and ribavirin-free regimen to treat hepatitis C. Three phase 3 trials (ION-1, ION-2, and ION-3) have demonstrated SVR rates consistently above 90%. The 24-week regimen for treatment-experienced cirrhotic patients is very expensive; recent data have shown that treatment-experienced patients with genotype 1 and compensated cirrhosis can have the regimen shortened to 12 weeks if ribavirin is added. Ledipasvir-sofosbuvir is a recommended therapy for patients with genotype 1, 4, 5, and 6 in the American Association for the Study of Liver Diseases, Infectious Diseases Society of America, (AASLD/IDSA) guidance. In addition, ledipasvir-sofosbuvir is a very attractive option for treatment of hepatitis C in persons coinfected with HIV.


You should check with your doctor immediately if any of these side effects occur when taking ledipasvir / sofosbuvir:

Incidence not known:

  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • shortness of breath
  • slow or irregular heartbeat
  • unusual tiredness