Active substance | Sofosbuvir + Ledipasvir |
US Brand | Generic Harvoni |
IN Brand | Ledifos | Hepcinat LP | MYHEP | LEDIHEP |
Manufacturing by | Hetero | Natco | Mylan | Zydus |
Strength | 400mg + 90mg |
Form release | Bottle 28 tablets |
Estimated shipping time | 7 – 18 days (Depending from the Country) |
Availability, Prices & Order | through request form |
Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.
http://www.hepatitisc.uw.edu/page/treatment/drugs/ledipasvir-sofosbuvir
The fixed dose combination of ledipasvir-sofosbuvir provides a very attractive and effective one pill once a day option for treatment of genotypes 1, 4, 5, and 6 chronic hepatitis C infection. This regimen is the first FDA-approved interferon- and ribavirin-free regimen to treat hepatitis C. Three phase 3 trials (ION-1, ION-2, and ION-3) have demonstrated SVR rates consistently above 90%. The 24-week regimen for treatment-experienced cirrhotic patients is very expensive; recent data have shown that treatment-experienced patients with genotype 1 and compensated cirrhosis can have the regimen shortened to 12 weeks if ribavirin is added. Ledipasvir-sofosbuvir is a recommended therapy for patients with genotype 1, 4, 5, and 6 in the American Association for the Study of Liver Diseases, Infectious Diseases Society of America, (AASLD/IDSA) guidance. In addition, ledipasvir-sofosbuvir is a very attractive option for treatment of hepatitis C in persons coinfected with HIV.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking ledipasvir / sofosbuvir:
Incidence not known:
- Chest pain or discomfort
- lightheadedness, dizziness, or fainting
- shortness of breath
- slow or irregular heartbeat
- unusual tiredness