Active substance Sofosbuvir + Ledipasvir
US Brand Generic Harvoni
IN Brand Ledifos | Hepcinat LP | MYHEP | LEDIHEP
Manufacturing by Hetero | Natco | Mylan | Zydus
Strength 400mg + 90mg
Form release Bottle 28 tablets
Estimated shipping time 7 – 18 days (Depending from the Country)
Availability, Prices & Order through request form

DescriptionDosageSide EffectsPhotos

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

http://www.hepatitisc.uw.edu/page/treatment/drugs/ledipasvir-sofosbuvir

The fixed dose combination of ledipasvir-sofosbuvir provides a very attractive and effective one pill once a day option for treatment of genotypes 1, 4, 5, and 6 chronic hepatitis C infection. This regimen is the first FDA-approved interferon- and ribavirin-free regimen to treat hepatitis C. Three phase 3 trials (ION-1, ION-2, and ION-3) have demonstrated SVR rates consistently above 90%. The 24-week regimen for treatment-experienced cirrhotic patients is very expensive; recent data have shown that treatment-experienced patients with genotype 1 and compensated cirrhosis can have the regimen shortened to 12 weeks if ribavirin is added. Ledipasvir-sofosbuvir is a recommended therapy for patients with genotype 1, 4, 5, and 6 in the American Association for the Study of Liver Diseases, Infectious Diseases Society of America, (AASLD/IDSA) guidance. In addition, ledipasvir-sofosbuvir is a very attractive option for treatment of hepatitis C in persons coinfected with HIV.

 

You should check with your doctor immediately if any of these side effects occur when taking ledipasvir / sofosbuvir:

Incidence not known:

  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • shortness of breath
  • slow or irregular heartbeat
  • unusual tiredness