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In a study, Aromasin dosed at 25mg per day increased total testosterone by 60% in only 10 days. Even better than that, is the fact that free (useable) testosterone increased over 100% in the same time frame! In addition, Aromasin also increases IGF-1 levels. There is no estrogen rebound from Aromasin, and it is also a very powerful and effective treatment for gynecomastia. All of this makes Aromasin a no-brainer for post cycle therapy as well as on cycle estrogen control.
Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy. US FDA approval was in October 2005.
Exemestane is also indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Aromasin or Exemstane produces side effects that are directly linked to the reduction of estrogen levels. Hot flashes, headaches and joint pain are commonly encountered by women. These side effects are usually mild.
Many women also experience moods swings and depression. Sleep disorders are also common. A complication that can develop due to brand or generic Aromasin treatment is osteoporosis which can lead to frequent fractures. Supplements to nourish and strengthen bones are prescribed to prevent this condition.
Exemstane is prescribed only for women post menopause as it acts on estrogen produced from the adrenal glands and not the ovaries (as in women who are still menstruating). It can impair reproduction in fertile women and can harm unborn babies. Liver problems have been associated with brand or generic Aromsin, but liver failure is rare. Individuals with liver metastases are more likely to have liver side effects which are evident from elevated levels of liver secretions in blood. The use of this drug, like other treatments for cancer, puts individuals at a slightly elevated risk for other cancers like that of the liver and kidneys. If you are on this medication for cardiovascular problems you have to report this to your doctor. Aromisin can cause changes in blood pressure and rarely heart conditions like a blockage.
or patients suffering from advanced breast cancer, Aromasin treatment should continue till the tumor progression is evident.
The recommended dosage of Aromasin for patients using potent CYP 3A4 inducer like phenytoin or rifampicin is 50 mg to be taken once daily after a meal.
According to the experiments with exemestane at repetitive doses up to 200 mg every day that established a moderate increase in non-fatal adverse events, dosage of Aromasin did not appear to be changed or altered.