Active substance Rifaximin
US Brand Xifaxan
IN Brand Rifagut
Manufacturing by SunPharma
Strength 200mg, 400mg, 550mg
Form release Blister 10 tablets
Estimated shipping time 7 – 18 days (Depending from the Country)
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DescriptionDosageSide Effects

Decreasing the risk that hepatic encephalopathy (a serious liver problem) will occur again in patients who have already had it. It may be used for other conditions as determined by your doctor.

Rifaximin is an antibiotic. Exactly how it works to treat hepatic encephalopathy is not known. It is thought to have an effect on the bacteria in the stomach.

This medication is used to treat diarrhea caused by the common bacteria known as E. coli (“traveler’s diarrhea”). Rifaximin should not be used if you have a fever or bloody diarrhea. It works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

Rifaximin is also used to treat irritable bowel syndrome with diarrhea. It is also used to prevent a brain problem caused by liver disease (hepatic encephalopathy). It may help you think more clearly.

200 mg orally 3 times a day for 3 days

Comments:
-Should not use in patients with diarrhea complicated by fever and/or blood in the stool or diarrhea caused by pathogens other than Escherichia coli

Use: For the treatment of travelers’ diarrhea due to noninvasive strains of E coli

550 mg orally twice a day

Comments:
-In trials, lactulose was used concomitantly in 91% of patients; differences in treatment effect of patients not using concomitant lactulose could not be assessed.

Use: For reduction in risk of overt hepatic encephalopathy recurrence

550 mg orally 3 times a day for 14 days

Comments:
-If symptoms recur, patients can be retreated up to 2 times with the same dose regimen.

Use: For the treatment of irritable bowel syndrome with diarrhea

12 years or older: 200 mg orally 3 times a day for 3 days

Comments:
-Should not use in patients with diarrhea complicated by fever and/or blood in the stool or diarrhea caused by pathogens other than E coli

Use: For the treatment of travelers’ diarrhea due to noninvasive strains of E coli

Data not available

Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Caution is recommended.

Comments:
-This drug was not studied in hepatic encephalopathy patients with Model for End-stage Liver Disease (MELD) scores greater than 25; in the controlled trial, only 8.6% of patients had MELD scores over 19.
-Systemic exposure increased with more severe liver dysfunction.

Travelers’ diarrhea: Safety and efficacy have not been established in patients younger than 12 years.
Hepatic encephalopathy, irritable bowel syndrome with diarrhea: Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Commonly reported side effects of rifaximin include: flatulence. Other side effects include: abdominal pain, bowel urgency, headache, nausea, and rectal tenesmus. See below for a comprehensive list of adverse effects.