Accutane (Isotretinoin)

Vitamin A derivative
It can treat acne.

Active Substance: Isotretinoin
US Brand: Accutane
Indian Brand: ISOTROIN
Manufacturing: CIPLA
Dosage: 10mg /20mg / 40mg
Form release: blister 10 pills
Shipping time: 9 – 18 days
Alcohol: Interactions can occur

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Very common

More than 3 million US cases per year

acne
A skin condition that occurs when hair follicles plug with oil and dead skin cells.
Acne is most common in teenagers and young adults.
Symptoms range from uninflamed blackheads to pus-filled pimples or large, red, and tender bumps.
Treatments include over-the-counter creams and cleanser, as well as prescription antibiotics.
Ages affected
0-2
Very common
3-5
Rare
6-13
Common
14-18
Very common
19-40
Very common
41-60
Common
60+
Rare

Isotretinoin (INN), also known as 13-cis-retinoic acid, is an oral pharmaceutical drug primarily used to treat severe nodular acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.

Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2–3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule’s close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.

In the United States a special procedure is required to obtain the pharmaceutical. In most other countries a consent form is required which explains these risks. Women taking isotretinoin must not get pregnant during, and for 1 month after isotretinoin therapy. Sexual abstinence, or effective contraception is mandatory during this period. Barrier methods by themselves (such as condoms) are not considered adequate due to the unacceptable failure rates of approximately 3%. Women who fall pregnant whilst on isotretinoin therapy are generally counselled to have a termination. Isotretinoin has no effect on male reproduction.

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