Active substance | Cefpodoxime |
US Brand | Vantin |
IN Brand | Cefoprox |
Manufacturing by | Cipla, India |
Strength | 100mg, 200mg |
Form release | blister 10 tablets |
Estimated shipping time | 7 – 18 days (Depending from the Country) |
Availability, Prices & Order | through request form |
Cefpodoxime is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Currently, it is only marketed as generic preparations in the USA, according to the FDA Orange Book. It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.
Zoetis markets cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day.
Finecure, India markets the products under trade name Cefpo.
Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is indicated in community acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections.
Usual Adult Dose for Bronchitis
Acute bacterial exacerbation of chronic bronchitis: 200 mg orally every 12 hours for 10 days
Usual Adult Dose for Cystitis
100 mg orally every 12 hours for 7 days
Usual Adult Dose for Gonococcal Infection – Uncomplicated
Uncomplicated urethral, cervical, or female anorectal infections: 200 mg orally one time
Alternatively, the Centers for Disease Control and Prevention suggest 400 mg orally one time may be effective for both male and female patients as an oral alternative for the treatment of uncomplicated gonorrhea of the cervix, urethra, or rectum.
Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.
The patient’s sexual partner(s) should also be evaluated/treated.
Cefpodoxime is not indicated for pharyngeal N gonorrhoeae infections.
Usual Adult Dose for Gonococcal Infection – Disseminated
400 mg orally twice a day
Initial therapy for disseminated gonococcal infections requires parenteral therapy which should be continued for 24 to 48 hours after clinical improvement is observed. Oral therapy may then be administered to complete a total course of at least 1 week.
Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.
The patient’s sexual partner(s) should also be evaluated/treated.
Usual Adult Dose for Pneumonia
Community-acquired pneumonia: 200 mg orally every 12 hours for 14 days
Diarrhea, nausea/vomiting, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.