Usual Adult Dose for Actinomycosis
500 mg orally 3 times a day or 875 mg orally twice a day for six months
Initial treatment of actinomycosis should include high dose parenteral penicillin G or ampicillin for 4 to 6 weeks, followed by appropriate oral therapy.
Usual Adult Dose for Anthrax Prophylaxis
500 mg orally every 8 hours
Oral amoxicillin is not considered first-line treatment for anthrax prophylaxis; it may, however, be used to complete a 60-day prophylactic course after 10 to 14 days of ciprofloxacin or doxycycline in pregnant or lactating patients or in patients with contraindications to the other two agents. The total duration of antimicrobial therapy is 60 days.
Usual Adult Dose for Cutaneous Bacillus anthracis
Treatment for confirmed cases of cutaneous Bacillus anthracis infection: 500 mg orally three times a day
Oral amoxicillin is not considered first-line treatment for the treatment of cutaneous anthrax; it may, however, be used to complete the treatment course once clinical response to ciprofloxacin or doxycycline has been observed or if the patient has contraindications to the other two agents. The total duration of antimicrobial therapy is 60 days.
Usual Adult Dose for Bacterial Endocarditis Prophylaxis
2 g orally given one hour prior to the procedure
Amoxicillin is considered the standard agent for prophylaxis against bacterial endocarditis in at-risk individuals undergoing certain dental, oral, respiratory tract or esophageal procedures.
Amoxicillin is not appropriate as endocarditis prophylaxis for patients identified as high-risk, including those with prosthetic heart valves, prior endocarditis, and those who have had surgically constructed systemic shunts or conduits. These patients should receive appropriate parenteral antimicrobial therapy.
Usual Adult Dose for Chlamydia Infection
500 mg orally 3 times a day for 7 days in pregnant patients as an alternative to erythromycin in macrolide-sensitive individuals
Amoxicillin does not have reliable activity against Chlamydia trachomatis.
Usual Adult Dose for Cystitis
250 to 500 mg orally 3 times a day for 3 to 7 days; alternatively, 500 to 875 mg orally twice a day may be administered
Usual Adult Dose for Urinary Tract Infection
250 to 500 mg orally 3 times a day for 3 to 7 days; alternatively, 500 to 875 mg orally twice a day may be administered
Usual Adult Dose for Helicobacter pylori Infection
1 g orally 2 to 3 times a day for 14 days
Amoxicillin is used in combination with metronidazole and bismuth subsalicylate or with clarithromycin and a proton-pump inhibitor such as omeprazole or lansoprazole.
Usual Adult Dose for Lyme Disease – Arthritis
500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.
Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.
Usual Adult Dose for Lyme Disease – Carditis
500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.
Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.
Usual Adult Dose for Lyme Disease – Erythema Chronicum Migrans
500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.
Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.
Usual Adult Dose for Lyme Disease – Neurologic
500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.
Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.
Usual Adult Dose for Otitis Media
250 to 500 mg orally 3 times a day for 10 to 14 days; alternatively, 500 to 875 mg orally twice a day may be administered
Usual Adult Dose for Pneumonia
500 mg orally 3 times a day or 875 mg orally twice a day may be administered for 7 to 10 days if pneumococcal pneumonia is suspected
Only mild pneumonia due to pneumococcus should be treated with amoxicillin.
Usual Adult Dose for Sinusitis
250 to 500 mg orally 3 times a day for 10 to 14 days; alternatively, 500 to 875 mg orally twice a day may be administered
Longer courses of therapy, up to 3 or 4 weeks, may be required in refractory or recurrent cases.
Usual Adult Dose for Skin or Soft Tissue Infection
250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered
Usual Adult Dose for Upper Respiratory Tract Infection
250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered
Usual Adult Dose for Bronchitis
250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered
Usual Adult Dose for Tonsillitis/Pharyngitis
Immediate-release: 250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered
Extended-release: 775 mg orally once a day within 1 hour after a meal for 10 days; for infections secondary to Streptococcus pyogenes
Usual Adult Dose for Bacterial Infection
250 to 500 mg orally 3 times a day for 7 to 21 days; alternatively, 500 to 875 mg orally twice a day may be administered