|IN Brand||Erlonat, Erlocip|
|Manufacturing by||Natco, Cipla, India|
|Form release||bottle 30 tablets|
|Estimated shipping time||7 – 18 days (Depending from the Country)|
|Availability, Prices & Order||through request form|
Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
Treating certain types of advanced or metastatic lung cancer. It is also used to treat certain types of pancreatic cancer in combination with another medicine (gemcitabine).
Erlotinib is a tyrosine kinase inhibitor. It works by helping to stop cancer cells from growing.
Usual Adult Dose for Non-Small Cell Lung Cancer
150 mg orally once a day
Duration of therapy: Until disease progression or unacceptable toxicity
-There is no evidence that treatment beyond disease progression is beneficial.
-First-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations.
-Maintenance treatment of patients with locally advanced or metastatic NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy.
-Treatment of locally advanced or metastatic NSCLC after failure of at least one prior chemotherapy regimen.
Common side effects
More than 10 in every 100 people have one or more of these.
- Skin changes occur in about 3 in 4 people (75%) – you may have a rash, blistering, or red, dry, skin, which usually starts within 10 days of starting erlotinib. If it is severe your doctors may reduce the dose or stop treatment
- Sensitivity of the skin to sunlight – cover up with clothing and use sunscreen if you need to go out into the sun
- An increased risk of getting an infection from a drop in white blood cells – it is harder to fight infections and you can become very ill. You may have headaches, aching muscles, a cough, a sore throat, pain passing urine, or you may feel cold and shivery. If you have a severe infection this can be life threatening. Contact your treatment centre straight away if you have any of these effects or if your temperature goes above 38°C. You will have regular blood tests to check your blood cell levels
- Itching affects just over 1 in 10 people (13%)
- Diarrhoea affects up to 1 in 2 people (50%) but is usually mild – tell your doctor or nurse if it is not controlled as they can prescribe medicines to stop it
- Loss of appetite and weight loss happen in about 1 in 2 people (50%)
- Tiredness and weakness (fatigue) happens in up to 1 in 2 people (50%)
- Feeling sick affects just over 3 in 10 (33%) people – it is usually well controlled with anti sickness medicines. Let your doctor or nurse know if it is not controlled
- Numbness in the hands and feet – tell your doctor or nurse if you have this
- Sore, red eyes or dry eyes affect up to 1 in 4 people (25%) – eye drops can help. Let your doctor or nurse know straight away if you have sudden or worsening eye redness or pain, watery eyes, or blurred vision and sensitivity to light
- A sore mouth occurs in 1 in 5 people (20%)
- Sadness, anxiety and depression affect about 1 in 10 people (10%)
- Breathlessness and a cough due to lung inflammation
- Stomach pain, indigestion and wind (flatulence)
- Liver changes that are very mild and unlikely to cause symptoms – they will almost certainly go back to normal when treatment ends. You will have regular blood tests to check how well your liver is working
- Loss of fertility – you may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Men may be able to store sperm before starting treatment
- Hair loss – hair growth on the head may be thinner or hair may be lost completely