Generic Baclofen (Lioresal)

Active Substance: Baclofen
US Brand: Lioresal
Indian (selling) Brand: Liofen
Manufacturing: Sunpharma
Dosage: 10mg / 25mg
Form release: blister 10 pills
Shipping time: 9 – 18 days

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Baclofen – a muscle relaxant central action, a derivative of gamma-aminobutyric acid (GAMKb-stimulant). By reducing the excitability of the terminal parts of afferent sensory fibers and suppressing the intermediate neurons, depresses mono-and polysynaptic transmission of nerve impulses; It reduces the prestressing muscle spindles. It has no effect on neuromuscular transmission. In neurological diseases involving spasticity of the skeletal muscles, reduces the painful spasms and clonic convulsions; increases range of motion in the joints, facilitates passive and active kinesitherapy (exercise, massage, manual therapy).


It enhances the action of drugs affecting the central nervous system, hypotensive and arthrifuge drugs, ethanol.
Tricyclic antidepressants increase the decreased muscle tone; levodopa, carbidopa in combination with levodopa increases the risk of hallucinations, confusion, agitation.

Special instructions:

In patients with liver disease and diabetes should periodically monitor the activity of “liver” transaminases, alkaline phosphatase, glucose.
During treatment should refrain from potentially hazardous activities related to the need for increased attention and rapid mental and motor responses.

Dosage and administration:

Baclofen is prescribed inside during the meal.
The initial dose of – 5 mg 3 times a day, followed by increasing doses every 3 days by 5 mg to achieve an effect, typically not more than 20-25 mg three times a day; the maximum dose – 100 mg / day (for a short time in the hospital). Final dose is set so as to decrease the muscle tone does not result in excessive and not worsen the myasthenia motor function.
If you are sensitive initial daily dose – 5-10 mg, followed by a slower increase.
In chronic renal insufficiency and during hemodialysis daily dose of 5 mg.
Children under 10 years of daily dose – 0.75-2 mg / kg, over 10 years old – 2.5 mg / kg; the initial dose – 1.5-2 mg / kg 4 times a day, maintenance dose for children 1-2 years – 10-20 mg / day, 2-10 years – 30-60 mg / day. Abolition of the drug was gradually (within 1-2 weeks).