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Amoxicillin also spelled amoxycillin, is an antibiotic useful for the treatment of a number of bacterial infections. It is the first line treatment for middle ear infections. It may also be used for strep throat, pneumonia, skin infections, and urinary tract infections among others.

Amoxicillin is used in the treatment of a number of infections, including acute otitis media, streptococcal pharyngitis, pneumonia, skin infections, urinary tract infections, Salmonella infections, Lyme disease, and chlamydia infections.

Usual Adult Dose for Actinomycosis

500 mg orally 3 times a day or 875 mg orally twice a day for six months
Initial treatment of actinomycosis should include high dose parenteral penicillin G or ampicillin for 4 to 6 weeks, followed by appropriate oral therapy.

Usual Adult Dose for Anthrax Prophylaxis

500 mg orally every 8 hours

Oral amoxicillin is not considered first-line treatment for anthrax prophylaxis; it may, however, be used to complete a 60-day prophylactic course after 10 to 14 days of ciprofloxacin or doxycycline in pregnant or lactating patients or in patients with contraindications to the other two agents. The total duration of antimicrobial therapy is 60 days.

Usual Adult Dose for Cutaneous Bacillus anthracis

Treatment for confirmed cases of cutaneous Bacillus anthracis infection: 500 mg orally three times a day

Oral amoxicillin is not considered first-line treatment for the treatment of cutaneous anthrax; it may, however, be used to complete the treatment course once clinical response to ciprofloxacin or doxycycline has been observed or if the patient has contraindications to the other two agents. The total duration of antimicrobial therapy is 60 days.

Usual Adult Dose for Bacterial Endocarditis Prophylaxis

2 g orally given one hour prior to the procedure

Amoxicillin is considered the standard agent for prophylaxis against bacterial endocarditis in at-risk individuals undergoing certain dental, oral, respiratory tract or esophageal procedures.

Amoxicillin is not appropriate as endocarditis prophylaxis for patients identified as high-risk, including those with prosthetic heart valves, prior endocarditis, and those who have had surgically constructed systemic shunts or conduits. These patients should receive appropriate parenteral antimicrobial therapy.

Usual Adult Dose for Chlamydia Infection

500 mg orally 3 times a day for 7 days in pregnant patients as an alternative to erythromycin in macrolide-sensitive individuals

Amoxicillin does not have reliable activity against Chlamydia trachomatis.

 

Usual Adult Dose for Cystitis

250 to 500 mg orally 3 times a day for 3 to 7 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Urinary Tract Infection

250 to 500 mg orally 3 times a day for 3 to 7 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Helicobacter pylori Infection

1 g orally 2 to 3 times a day for 14 days
Amoxicillin is used in combination with metronidazole and bismuth subsalicylate or with clarithromycin and a proton-pump inhibitor such as omeprazole or lansoprazole.

Usual Adult Dose for Lyme Disease – Arthritis

500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.

Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.

Usual Adult Dose for Lyme Disease – Carditis

500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.

Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.

Usual Adult Dose for Lyme Disease – Erythema Chronicum Migrans

500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.

Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.

Usual Adult Dose for Lyme Disease – Neurologic

500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.

Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.

Usual Adult Dose for Otitis Media

250 to 500 mg orally 3 times a day for 10 to 14 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Pneumonia

500 mg orally 3 times a day or 875 mg orally twice a day may be administered for 7 to 10 days if pneumococcal pneumonia is suspected
Only mild pneumonia due to pneumococcus should be treated with amoxicillin.

Usual Adult Dose for Sinusitis

250 to 500 mg orally 3 times a day for 10 to 14 days; alternatively, 500 to 875 mg orally twice a day may be administered
Longer courses of therapy, up to 3 or 4 weeks, may be required in refractory or recurrent cases.

Usual Adult Dose for Skin or Soft Tissue Infection

250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Upper Respiratory Tract Infection

250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Bronchitis

250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Tonsillitis/Pharyngitis

Immediate-release: 250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered
Extended-release: 775 mg orally once a day within 1 hour after a meal for 10 days; for infections secondary to Streptococcus pyogenes

Usual Adult Dose for Bacterial Infection

250 to 500 mg orally 3 times a day for 7 to 21 days; alternatively, 500 to 875 mg orally twice a day may be administered

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Blistering, peeling, or red skin rash

Diarrhea that may contain blood, stomach cramps, fever

If you notice these less serious side effects, talk with your doctor:

Mild diarrhea, nausea, or vomiting

Mild skin rash

If you notice other side effects that you think are caused by this medicine, tell your doctor.